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Clotrimazole as a pharmaceutical: past, present and future

Clotimazole is an effective, safe and well-tolerated drug with an unusual chemistry that is widely used in the treatment of skin, vulvovaginal and oropharyngeal fungal infections. It is sold in most developed countries worldwide under a variety of trade names, and a large number of clotrimazole formulations are available. Although emerging resistance to clotrimazole may limit the future use of this drug in certain patient subpopulations, in the general population, its widespread use is likely to continue for the foreseeable future. Ongoing development of clotrimazole as a pharmaceutical is currently focused on finding new clinical indications for the drug, its use as a lead compound in structure-based…

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Articles of Interest

Clotrimazole

Clotrimazole is one of the most common topical antifungal medicines sold at pharmacies. Clotrimazole is commonly sold as a generic product, but it is also available under the brand names of Alevazol, Lotrimin AF, Gyne-Lotrimin, etc. Clotrimazole can be used to treat either skin-based or vaginal fungal infections. It is used to treat tinea corporis (ringworm), tinea cruris (fungal infection in the groin or buttocks area; often called “jock itch”), tinea pedis (fungal infection on the foot; often called “athlete’s foot”), or vulvovaginal candidiasis (vaginal fungal infection; often called a “yeast infection”). Clotrimazole is available as a skin cream, ointment, external liquid solution, and vaginal cream. Clotrimazole is very similar to miconazole. Clotrimazole and miconazole fall into the same category of antifungals.

Clotrimazole for Vulvovaginal Candidosis: More Than 45 Years of Clinical Experience

Vulvovaginal candidosis is a common disease, and various treatment strategies have emerged over the last few decades. Clotrimazole belongs to the drugs of choice for the treatment of vulvovaginal candidosis. Although available for almost 50 years, systematic reviews on the usefulness of topical clotrimazole across disease severity and populations affected are scarce.

Comparing the effects of Mycozin and Clotrimazole 1% creams on vaginal candidiasis...

The results of the study showed that Mycozin vaginal cream was as effective as Clotrimazole 1% vaginal cream in eliminating most of the symptoms, signs and laboratory results.

Synapse Simplified: How to Find Clotrimazole Information

Clotrimazole, a diminutive molecule of pharmacological relevance, exerts its influence as an astoundingly powerful CYP51A1 inhibitor. This enzyme, paramount in the biosynthesis of ergosterol, a fundamental building block of fungal cell membranes, is the key target for clotrimazole's inhibitory prowess.

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Clotrimazole

Clotrimazole is an imidazole derivative that was first discovered in 1967. Clotrimazole damages the fungal cell wall, which alters its permeability, leading to a loss of essential intracellular elements. It is active against a variety of fungi including Candida albicans, Trichophyton species, Microsporum species, and Aspergillus species; resistance is rare. Clotrimazole is commonly used to treat various topical fungal infections, including tinea corporis, tinea cruris, tinea pedis, and tinea versicolor.

StatPearls

Clotrimazole is a synthetic imidazole with a broad spectrum of antimycotic activity. Clotrimazole is an FDA-approved drug to treat oral candidiasis, vulvovaginal candidiasis, and dermatomycoses. This drug is an effective treatment for skin infections such as athlete's foot, jock itch, ringworm, pityriasis versicolor, intertrigo, and erythrasma. Additionally, clotrimazole has some activity against certain gram-positive bacteria and, at very high concentrations, has activity against Trichomonas...