HWN Suggests

Miconazole: a historical perspective

This agent is distinguished from other azoles by possessing two mechanisms of action. The first mechanism is shared with other azoles and involves the inhibition of ergosterol synthesis. Another mechanism involves inhibition of peroxidases, which results in the accumulation of peroxide within the cell resulting in cell death. Susceptibility patterns for miconazole demonstrate that yeast fungi remain largely susceptible even in light of repeated exposures. Despite the release of newer azoles and other classes of antifungals, miconazole remains a highly prescribed treatment for vaginal candidiasis.

read full article

Featured

 Miconazole

Miconazole is another common antifungal agent, and it is available as a generic product and under many different brand names (Desenex, Micaderm, Monistat, etc). Miconazole is an antifungal drug of choice for vaginal yeast infections. It can also be used to treat ringworm, jock itch, or athlete’s foot. Miconazole is available as an aerosol, aerosol powder, skin cream, vaginal cream, ointment, powder, external liquid solution, and vaginal suppository. Creams and solutions for nonprescription antifungals are typically more effective than powders and aerosols. Miconazole is very similar to clotrimazole. Thus, the effectiveness of miconazole is comparable to clotrimazole. Clotrimazole is utilized more commonly for skin infections and miconazole is utilized more commonly for vaginal infections, but both can be used for either purpose. Clotrimazole and miconazole are both used twice per day for up to 4 weeks. Both of these products can be used in individuals 2 years of age or older.

Articles of Interest

Fluconazole (Diflucan®) vs. Miconazole (Monistat®): Which is Best for Yeast Infections?

For general, uncomplicated treatment of yeast infections either fluconazole or miconazole is effective for 80-90% of users that complete treatment. However, some outside factors could determine which treatment is best in that specific case. For example, topical miconazole can weaken latex condoms so either sex should be avoided during treatment or oral treatment may be prescribed. Pregnant and diabetic women should only seek lower-dose topical treatment for yeast infections. Lastly, fluconazole oral treatment can be used as a preventative for reoccurring or chronic yeast infections.

How Miconazole Nitrate Treats Fungal Infections Effectively

Miconazole nitrate works by targeting the cell membrane of fungi. It inhibits an enzyme called ergosterol, which is essential for building and maintaining the fungal cell membrane. Without ergosterol, the cell membrane weakens, causing the fungi to die.

Ketoconazole Cream (Nizoral) vs. Miconazole (Monistat)

Miconazole is an antifungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). It is used either on the skin or in the to treat vaginal infections and other infections (athlete's foot, ringworm), and severe fungal infections.