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Terbinafine Cream for Fungal Infections: What You Need To Know

Terbinafine cream has been around in the U.S. since 1996. And since that time it has been a popular over-the-counter treatment for skin fungal infections. You may recognize the brand name Lamisil, the active ingredient inside Lamisil is Terbinafine... If you are treating a fungal infection on the skin, you will normally need to treat for 7-28 days, depending on which skin infection you have.

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 Terbinafine Therapeutic Cheat Sheet

Oral and topical formulations of terbinafine are commonly used on- and off-label for the treatment of numerous dermatophyte infections.

Articles of Interest

A comparison of terbinafine (Lamisil) 1% cream given for one week with clotrimazole (Canesten) 1%

The results show that 1 week of terbinafine b.d. is more effective than 4 weeks of clotrimazole b.d., in terms of both mycological cure and effective treatment.

Evaluation of Association Between Oral and Topical Terbinafine Use in Pregnancy

While terbinafine is a commonly used effective antifungal agent and generally well tolerated in the nonpregnant population, limited data exist on the fetal safety of use in pregnancy.

One week terbinafine 1% cream (Lamisil®) once daily is effective in the treatment of interdigital tinea pedis

We conclude that terbinafine 1% cream, applied once daily for 7 days, is an effective and well-tolerated treatment for interdigital tinea pedis in non-immunocompromised patients. The short duration of treatment needed to achieve mycological cure has important implications for patient compliance and for control of infection within the community.

Open clinical study of the efficacy and safety of terbinafine cream 1% in children with tinea corporis and tinea cruris

Terbinafine 1% cream appears to be an effective and well-tolerated treatment for tinea corporis and tinea cruris in children.

Systemic absorption and safety of topical terbinafine hydrochloride 10% solution

In this study, terbinafine hydrochloride 10% solution (MOB015B)—administered under maximal use conditions—was found to be safe and well-tolerated with no reported severe TEAEs, serious AEs, or AEs leading to study discontinuation. The plasma terbinafine levels in MOB015B treated patients were significantly lower than those of oral terbinafine indicating a lower systemic exposure risk.

Terbinafine Monograph - Paediatric

• Not routinely used in children under 12 months of age or weighing less than 10 kg.

Topical Delivery of Terbinafine HCL Using Nanogels: A New Approach to Superficial Fungal Infection Treatment

In vivo studies conducted on animal models infected with a fungal infection have further confirmed the effectiveness of nanogels compared with the Lamisil cream. Hence, Gelatin-g-poly-(acrylic acid) nanogels carrying poorly soluble TBH can be a promising approach for treating superficial fungal infections.

Topical management of tinea pedis

Tinea pedis is successfully treated with topical antifungals in 70% to 75% of patients compared with 20% to 30% using placebo. Tea tree oil is likely ineffective. Topical terbinafine might result in an absolute improvement of 2% to 8% more patients cured over other topicals. Most patients were treated for 1 week with terbinafine and 4 to 6 weeks with azoles (like clotrimazole).

Resources

Topical Terbinafine

Cures most athlete’s foot (tinea pedis), cures most jock itch (tinea cruris) and ringworm (tinea corporis), relieves itching, burning, cracking and scaling which accompany these conditions.