JAK Inhibitors

The Jakafi Report

In an anecdotal survey of 21 MPN patients taking Jakafi for relief of MF symptoms, first results vary from highly positive to unacceptable.

JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis

Janus kinase (JAK)/signal transducers and activators of transcription (STATs) are a group of molecules associated with one of the major pathways through which many cytokines exert and integrate their function, and as such they are increasingly recognized as playing critical role in the pathogenesis subserving various immune-mediated diseases, including RA, PsA, SpAs, IBD, skin disorders (e.g. alopecia areata, atopic dermatitis), single-gene disorders like interferonopathies, and others.

The arrival of JAK inhibitors: advancing the treatment of immune and hematologic disorders

Altered production of cytokines can result in pathologies ranging from autoimmune diseases to malignancies. The Janus Kinases family is a small group of receptor-associated signaling molecules that is essential to the signal cascade originating from type I and type II cytokine receptors.

Are Janus Kinase Inhibitors Superior over Classic Biologic Agents in RA Patients?

In recent years a substantial battery of evidence has been collected indicating the potential role of Jakinibs to interact with the specific elements of the immune system, therefore changing the inflammatory response. JAK kinase blockade offers a unique opportunity to block most of the key cytokines enabling the deep interaction into immune system functioning.

For Vitiligo Patients, New Treatments Offer Hope

“We now have a much better understanding of the immunological pathways involved in vitiligo, which is providing insight on how to target and treat the disease better,” an expert says.

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

Proof provided by biological therapies that cytokines are truly key drivers of immune-mediated diseases has spurred effort in targeting their associated signaling pathways. Small-molecule drugs that inhibit Janus kinases (jakinibs), which are essential signaling mediators downstream of many pro-inflammatory cytokines, have gained traction as safe and efficacious options for the treatment of inflammation-driven pathologies like rheumatoid arthritis, psoriasis and inflammatory bowel disease.

JAK Inhibitors for Rheumatoid Arthritis

In one study, about half of people with RA who didn't improve with biologic drugs had symptoms that were less severe after they took the JAK inhibitor tofacitinib for 3 months. Another advantage of JAK inhibitors is that you can take them by mouth.

JAK inhibitors for the treatment of rheumatoid arthritis

The treatment of rheumatoid arthritis has changed dramatically over the last two decades since the development of biological disease-modifying anti-rheumatic drugs (bDMARDs). Moreover, Janus kinase (JAK) inhibitors became available in 2013. JAK inhibitors are low-molecular-weight compounds, which exert anti-rheumatic effects by suppressing the action of JAK, an intracellular tyrosine kinase.

Janus kinase Inhibitors in autoimmune diseases

The critical function of Jaks in cytokine signaling has made them targets for industry to consider. At present there are a number of such inhibitors in clinical use or being tested in clinical trials.

The Consumer’s Guide to RA and JAK Inhibitors

Everything you need to know about the newest class of FDA-approved RA meds.

Eli Lilly Arthritis Drug Helped Hospitalized Covid-19 Patients Recover Faster

Drugmaker will seek emergency-use authorization for rheumatoid-arthritis drug Olumiant in coronavirus cases based on NIH study.

JAK Inhibition as a New Treatment Strategy for Patients with COVID-19

... considering the common role of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in AT1-R expressed on peripheral tissues and cytokine receptors on the surface of immune cells, potential targeting of this pathway using JAK inhibitors (JAKinibs) is suggested as a promising approach in patients with COVID-19 who are admitted to hospitals.

JAK inhibitors in COVID-19: the need for vigilance regarding increased inherent thrombotic risk

JAK inhibitors have promising therapeutic potential in COVID-19 with dual anti-inflammatory and anti-viral effects. Vigilance to the potentially increased thrombotic risk associated with JAKi is recommended, given the hypercoagulability of COVID-19.

The new entries in the therapeutic armamentarium: The small molecule JAK inhibitors

The past decade has witnessed an explosion in trial data on JAK inhibitors (JAKi). These small molecules target the Janus kinase - signal transducer and activator of transcription (JAK-STAT) pathway, blocking crucial cytokines across a septum of rheumatic diseases.

Jakafi

For the treatment of intermediate and high risk myelofibrosis. For the treatment of acute graft-versus-host (GVHD) not responsive steroids, in adults and pediatric patients 12 years of older.