“People don’t know about it, physicians don’t know about it, and we have to get an education program out there, but that’s expensive,” said Dr. Henry N. Ginsberg, the Irving Professor of Medicine at Columbia University and a leading expert on lp(a). “I would say that somewhere between 15 to 20 percent of the population would clearly benefit from knowing that this is their problem.”
Millions of Americans schedule an annual physical health examination. During their visit, many can expect to get their blood drawn for a standard lipid panel, which ultimately provides the patient with a readout of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TGs). What virtually nobody among them will get is an apolipoprotein B (apoB) test. Yet this is considered the ideal, if not essential, measurement to assess lipoprotein-related atherosclerotic cardiovascular disease (ASCVD) risk
It is not surprising that most PCPs don’t know very much about Lp(a). Although Lp(a) is well-researched, there is still a lot to learn about this complex lipoprotein.
Lp(a) is more related to LDL because it’s an LDL particle that contains apolipoprotein B linked to apo(a). So it’s a subclass of LDL but it’s a more atherogenic form of LDL. That means it’s a type of LDL that is linked to a higher risk of heart disease, much more so than LDL itself. The production of Lp(a) is controlled by a specific gene.
You may have heard about Lipoprotein (a), Lp(a) or often referred to as “Lp little a." Lp(a) is an independent risk factor for cardiovascular disease. The level of Lp(a) found in a person’s blood is entirely genetically predetermined. This means that unlike other cardiac risk factors, Lp(a) can’t be modified by diet or exercise. Your level of Lp(a) is the same at age 5 as at age 45. The only exception is that your level can increase at menopause and in certain disease states such as chronic kidney disease.
Lipoprotein(a) [Lp(a)], aka “Lp little a”, was discovered in the 1960s in the lab of the Norwegian physician Kåre Berg. Since then, we have greatly improved our knowledge of lipids and cardiovascular disease (CVD). Lp(a) is an enigmatic class of lipoprotein that is exclusively formed in the liver and comprises two main components, a single copy of apolipoprotein (apo) B-100 (apo-B100) tethered to a single copy of a protein denoted as apolipoprotein(a) apo(a).
High blood levels of a fatty particle called lipoprotein(a) may explain some unexpected premature heart attacks.
Most people have had their LDL cholesterol measured. Have you ever had your Lp(a) tested? Did you know that statins may actually raise this key risk factor?
Epidemiological and genetic studies have identified elevated levels of lipoprotein (a) ((Lp(a)) as a causal and independent risk factor for cardiovascular diseases (CVD).
Lipoprotein(a) (Lp[a]) has been identified as an independent, causal risk factor for cardiovascular disease (CVD).1, 2 Lp(a) has a structure similar to low‐density lipoprotein (LDL) in its lipid core composition in addition to a molecule of apolipoprotein B100 (apoB), but also contains a unique glycoprotein—apo(a), with strong structural homology with plasminogen
Lp(a) was first identified and classified as a “low density lipoprotein variant” over 40 years ago. Similar to low-density lipoprotein (LDL), but containing an additional protein, apo(a), Lp(a) has proven to be pathogenic in nature and involved in the development of coronary heart disease (CHD).
People with a family history of early heart disease need to be tested for this inherited cholesterol particle.
Why can heart attacks strike people who appear to be perfectly healthy? In some cases, the answer is a little-known risk, lipoprotein(a), which is rarely considered until its impact is felt. Here are 10 things to know about this quiet threat.
Preventing early heart attacks and strokes by advancing awareness, identification and treatment of Lipoprotein(a)
"To live in a world where high Lipoprotein(a) is routinely, diagnosed, treated and family screened."